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Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients.

作者信息

Grozdova M D, Khokhlova J V, Panasyuk A F, Guseva N G, Trofimova T M

出版信息

Arthritis Rheum. 1984 Oct;27(10):1144-9. doi: 10.1002/art.1780271010.

DOI:10.1002/art.1780271010
PMID:6091700
Abstract

Levels of cAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrine-induced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was abnormal in PSS cells. Considerable heterogeneity was observed in rheumatoid arthritis fibroblasts. Membrane-bound abnormalities in (PSS) cells may be of importance in the defective control of collagen production in progressive systemic sclerosis.

摘要

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