雷尼替丁与西咪替丁对胃酸分泌影响的对比研究。
Comparative study with ranitidine and cimetidine on gastric secretion.
作者信息
Sewing K F, Billian A, Malchow H
出版信息
Scand J Gastroenterol Suppl. 1981 Jun;69:45-9.
PMID:6119782
Abstract
The inihibitory effect of various doses of ranitidine and cimetidine on pentagastrin stimulated volume, acid, and pepsin secretion was studied in 8 healthy volunteers. Both compounds inhibited all three variables in a dose dependent manner with an average ID50 of approximately 5 mg for ranitidine and of approximately 41 mg for cimetidine. On a molar basis ranitidine is about 11 times more potent than cimetidine. The duration of action of both compounds appears to be equally long.
摘要
在8名健康志愿者中研究了不同剂量的雷尼替丁和西咪替丁对五肽胃泌素刺激的胃液量、胃酸和胃蛋白酶分泌的抑制作用。两种化合物均以剂量依赖性方式抑制所有这三个变量，雷尼替丁的平均半数抑制剂量（ID50）约为5毫克，西咪替丁约为41毫克。按摩尔计算，雷尼替丁的效力约为西咪替丁的11倍。两种化合物的作用持续时间似乎同样长。
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