Kodama T, Takada K, Kameya T, Shimosato Y, Tsuchiya R, Okabe T
Cancer. 1984 Nov 15;54(10):2313-7. doi: 10.1002/1097-0142(19841115)54:10<2313::aid-cncr2820541044>3.0.co;2-i.
A case of large cell carcinoma of the lung which produced eosinophil colony stimulating factor and eosinophil chemotactic factor was reported. A 52-year-old Japanese man with a tumor in the left upper lobe of the lung underwent left pneumonectomy. Marked eosinophilia persisted especially after recurrence, with a maximum peripheral leukocyte count of 161,000/mm3, of which 78% consisted of eosinophils. The patient died of pulmonary insufficiency 18 months after surgery. At autopsy, metastatic tumor tissues and almost all organs were markedly infiltrated with eosinophils, especially the spleen, and there was marked proliferation of eosinophils in the bone marrow. Eosinophil colony stimulating factor production by the transplanted tumor in a nude mouse was confirmed by use of a human bone marrow culture assay system. Eosinophil chemotactic factor production by metastatic tumor tissue also was proved by a modified micro-filter technique.
报告了一例产生嗜酸性粒细胞集落刺激因子和嗜酸性粒细胞趋化因子的肺大细胞癌病例。一名52岁的日本男性，左上肺有肿瘤，接受了左肺切除术。尤其是复发后，明显的嗜酸性粒细胞增多持续存在，外周白细胞计数最高达161,000/mm³，其中78%为嗜酸性粒细胞。患者术后18个月死于肺功能不全。尸检时，转移瘤组织和几乎所有器官都有明显的嗜酸性粒细胞浸润，尤其是脾脏，骨髓中嗜酸性粒细胞明显增殖。通过使用人骨髓培养测定系统，证实移植到裸鼠体内的肿瘤产生了嗜酸性粒细胞集落刺激因子。改良的微滤技术也证明了转移瘤组织产生了嗜酸性粒细胞趋化因子。
