Beekhuis H, Piers D A
Eur J Nucl Med. 1983;8(8):348-50. doi: 10.1007/BF00253544.
Tumor risk factors were calculated for newborns who were investigated for congenital hypothyroidism (CHT) with radionuclides by thyroid scintigraphy. Figures for three radiopharmaceuticals, 99mTc-pertechnetate, 123I-and 131I-sodium iodide for adults were extrapolated to newborns. The radiation dose to the normal thyroid gland in newborns was seven times higher for 123I-NaI than for 99mTcO-4, the somatically effective total body dose was two times higher for 123I-NaI than for 99mTcO-4. The use of 123I-NaI was preferred because of better scintigraphic results. Risk estimates for thyroid scintigraphy in newborns in the diagnostic work-up of CHT are given using published age-dependent tumor induction figures derived from atomic bomb survivors.
对通过甲状腺闪烁扫描术用放射性核素进行先天性甲状腺功能减退症（CHT）检查的新生儿计算肿瘤风险因素。将三种放射性药物（成人用的99m锝高锝酸盐、123I和131I碘化钠）的数据外推至新生儿。新生儿正常甲状腺接受的辐射剂量，123I碘化钠比99m锝高锝酸盐高7倍，躯体有效全身剂量123I碘化钠比99m锝高锝酸盐高2倍。由于闪烁扫描结果更好，优先使用123I碘化钠。利用从原子弹幸存者得出的已发表的年龄依赖性肿瘤诱发数据，给出了CHT诊断检查中新生儿甲状腺闪烁扫描的风险估计值。
