Bucca C, Veglio F, Rolla G, Cacciabue M, Cicconi C, Ossola M, Nuzzi A, Avolio G, Angeli A
Eur J Respir Dis. 1984 Oct;65(7):477-80.
Circulating Angiotensin Converting Enzyme (ACE) level, chest X-rays and respiratory function tests were determined in 76 male patients with silicosis. Mean serum ACE in the patients was significantly higher than in 30 healthy controls (129.8 +/- 4 U/ml and 92.4 +/- 22.7 respectively), although individual values were in the normal range in about half of the patients. Enzyme levels were independent of silica dust exposure, X-ray changes, functional lung impairment, age, smoking habits, and presence of chronic obstructive pulmonary disease. However, patients with more severe radiological changes tended to have lower ACE values. Our data confirm that serum ACE level is frequently raised in silicosis, but does not give further information in the evaluation of the disease.
对76例男性矽肺患者进行了循环血管紧张素转换酶（ACE）水平、胸部X光检查和呼吸功能测试。患者的平均血清ACE水平显著高于30名健康对照者（分别为129.8±4 U/ml和92.4±22.7 U/ml），尽管约一半患者的个体值在正常范围内。酶水平与二氧化硅粉尘暴露、X光变化、肺功能损害、年龄、吸烟习惯以及慢性阻塞性肺疾病的存在无关。然而，放射学改变较严重的患者往往ACE值较低。我们的数据证实，矽肺患者血清ACE水平经常升高，但在该疾病的评估中并未提供更多信息。
