Milanés M V, Cremades A, del Rio J
Gen Pharmacol. 1984;15(4):357-60. doi: 10.1016/0306-3623(84)90015-6.
Morphine 50 mg/kg i.p. produced a hypothermic effect in unrestrained guinea-pigs and this effect was potentiated when animals were restrained. The morphine-induced hypothermia was antagonized by dexamethasone treatment (1 mg/kg 24 hr and 0.5 mg/kg i.p. 2 hr before morphine). Treatment with the inhibitor of peptide biosynthesis cycloheximide (10 mg/kg i.p. 24 and 2 hr before morphine) also inhibited the hypothermic effect of morphine. ACTH injected intracerebroventricular produced no changes in body temperature. These results are consistent with the hypothesis that anterior pituitary peptide beta-endorphin may play a role in the hypothermic effect produced by morphine in the guinea-pig.
腹腔注射50毫克/千克吗啡对未拘束的豚鼠产生体温过低效应，当动物被拘束时此效应增强。吗啡诱导的体温过低被地塞米松治疗（在吗啡给药前24小时1毫克/千克及给药前2小时腹腔注射0.5毫克/千克）所拮抗。用肽生物合成抑制剂环己酰亚胺（在吗啡给药前24小时及给药前2小时腹腔注射10毫克/千克）治疗也抑制了吗啡的体温过低效应。脑室内注射促肾上腺皮质激素对体温无影响。这些结果与如下假说一致，即垂体前叶肽β-内啡肽可能在豚鼠吗啡产生的体温过低效应中起作用。
