Milanés M V, Del Rio-García J, Cremades A, Vargas M L
Brain Res. 1986 Jun 4;375(1):13-9. doi: 10.1016/0006-8993(86)90953-4.
Peripheral treatment with adrenocorticotropin (1-24) (ACTH1-24), at different doses and sequences, consistently antagonized the decrease in body temperature produced by morphine in the freely moving guinea pig, whereas adrenocorticotropin (4-10) (ACTH4-10), which lacks corticotrophic activity, was partially effective only when it was administered in a high dose 24 h prior to morphine. Centrally administered ACTH1-24 completely prevented the hypothermic effect of intracerebroventricularly (i.c.v.)-injected morphine. Likewise, the i.c.v. administration of ACTH4-10 was equally effective in blocking the i.c.v. morphine-induced hypothermia. Neither ACTH1-24 nor ACTH4-10 did produce changes in body temperature. These results suggest that peripherally administered ACTH1-24 antagonizes indirectly the actions of morphine through the release of adrenal corticosteroids, whereas centrally injected ACTH1-24 or ACTH4-10 act as direct antagonists of morphine effects through opioid receptors.
用不同剂量和给药顺序的促肾上腺皮质激素（1-24）（ACTH1-24）进行外周给药，能持续对抗吗啡引起的自由活动豚鼠体温下降，而缺乏促肾上腺皮质激素活性的促肾上腺皮质激素（4-10）（ACTH4-10），仅在吗啡给药前24小时高剂量给药时才部分有效。脑室内注射促肾上腺皮质激素（1-24）可完全预防脑室内注射吗啡的降温作用。同样，脑室内注射促肾上腺皮质激素（4-10）在阻断脑室内注射吗啡引起的体温过低方面同样有效。促肾上腺皮质激素（1-24）和促肾上腺皮质激素（4-10）均未引起体温变化。这些结果表明，外周注射促肾上腺皮质激素（1-24）通过肾上腺皮质激素的释放间接拮抗吗啡的作用，而脑室内注射促肾上腺皮质激素（1-24）或促肾上腺皮质激素（4-10）则通过阿片受体作为吗啡作用的直接拮抗剂。
