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对氧磷和甲基对硫磷对培养的人淋巴细胞的细胞遗传学效应：姐妹染色单体交换、致断裂活性和细胞周期延迟。

Cytogenetic effects of paraoxon and methyl-parathion on cultured human lymphocytes: SCE, clastogenic activity and cell cycle delay.

作者信息

Singh S, Lehmann-Grube B, Goedde H W

出版信息

Int Arch Occup Environ Health. 1984;54(3):195-200. doi: 10.1007/BF00379049.

DOI:10.1007/BF00379049
PMID:6092281
Abstract

Paraoxon and methyl-parathion (Wofatox), frequently used organophosphate pesticides, were tested for cytogenetic effects in lymphocytes of persons with different phenotypes of paraoxonase activity. Sister chromatid exchanges (SCE), chromosome breaks, and cell cycle traverse were studied in ten individuals. Paraoxon showed no significant effects whereas methyl-parathion showed a dose-dependent increase in the SCE and a definite delay in the cell cycle as assessed by fluorescence plus Giemsa technique. No significant clastogenic effects and no difference in response were observed among individuals with different phenotypes of paraoxonase.

摘要

对氧磷和甲基对硫磷（沃发托克斯）是常用的有机磷农药，我们对具有不同对氧磷酶活性表型的人的淋巴细胞进行了细胞遗传学效应测试。我们研究了10个人的姐妹染色单体交换（SCE）、染色体断裂和细胞周期进程。通过荧光加吉姆萨技术评估，对氧磷未显示出显著影响，而甲基对硫磷显示出SCE呈剂量依赖性增加以及细胞周期有明确延迟。在具有不同对氧磷酶表型的个体中未观察到显著的致断裂效应，且反应无差异。

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1
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Int Arch Occup Environ Health. 1984;54(3):195-200. doi: 10.1007/BF00379049.
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本文引用的文献

1
Induction of sister-chromatid exchanges and cell cycle delay in cultured mammalian cells treated with eight organophosphorus pesticides.八种有机磷农药处理的培养哺乳动物细胞中姐妹染色单体交换的诱导及细胞周期延迟
Mutat Res. 1981 Mar;88(3):307-16. doi: 10.1016/0165-1218(81)90042-2.
2
Cytogenetic study of workers exposed to methyl-parathion.
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3
An overview of short-term tests for the mutagenic and carcinogenic potential of pesticides.农药致突变性和致癌性短期测试概述。
J Environ Sci Health B. 1980;15(6):867-906. doi: 10.1080/03601238009372221.
4
Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay.
Hum Genet. 1983;63(3):285-9. doi: 10.1007/BF00284666.
5
Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.致突变性试验中的姐妹染色单体交换（SCE）和染色体结构畸变
Hum Genet. 1981;58(3):235-54. doi: 10.1007/BF00294917.
6
Plasma paraoxonase polymorphism: a new enzyme assay, population, family, biochemical, and linkage studies.血浆对氧磷酶多态性：一项新的酶分析、群体、家族、生化及连锁研究。
Am J Hum Genet. 1983 May;35(3):393-408.
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Embryotoxicity of acute exposure to methyl parathion in rats and mice.
Arch Environ Health. 1967 Nov;15(5):609-13. doi: 10.1080/00039896.1967.10664976.
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[Enzymatic hydrolysis of diethyl-p-nitrophenylphosphate (E 600) by human serum].[人血清对二乙基对硝基苯基磷酸酯（E600）的酶促水解作用]
Z Klin Chem Klin Biochem. 1968 Jan;6(1):41-5.
9
Lymphocyte chromosome analysis of agricultural workers during extensive occupational exposure to pesticides.大量接触农药的农业工人淋巴细胞染色体分析
Mutat Res. 1973 Dec;21(6):335-40.
10
A survey on the mutagenicity of various pesticides.关于各种农药致突变性的一项调查。
Experientia. 1973 May 15;29(5):622-3. doi: 10.1007/BF01926706.