• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay.

作者信息

Böhlke J U, Singh S, Goedde H W

出版信息

Hum Genet. 1983;63(3):285-9. doi: 10.1007/BF00284666.

DOI:10.1007/BF00284666
PMID:6852826
Abstract

Acetaldehyde, the first metabolite of ethanol oxidation, caused a dose-dependent linear increase in the induction of sister chromatid exchanges in lymphocytes from both Germans and Japanese. Japanese, possessing only aldehyde dehydrogenase II isozyme (ALDH I deficient phenotype) and showing adverse effects after alcohol ingestion, did not differ in SCE rates from Germans and Japanese possessing isozymes I and II. At acetaldehyde concentrations above 360 microM, a significant chromosome breaking effect and a definite delay in cell cycle events, as evaluated by the BdUrd labeling technique, was registered in all individuals. Pyridoxal 5'-phosphate showed no protective effect against acetaldehyde-induced SCE formation in our system. A 24-h extension of the normal culture period revealed significantly higher rates of SCE at acetaldehyde doses above 360 microM.

摘要

相似文献

1
Cytogenetic effects of acetaldehyde in lymphocytes of Germans and Japanese: SCE, clastogenic activity, and cell cycle delay.
Hum Genet. 1983;63(3):285-9. doi: 10.1007/BF00284666.
2
Increased frequency of acetaldehyde-induced sister-chromatid exchanges in human lymphocytes treated with an aldehyde dehydrogenase inhibitor.用醛脱氢酶抑制剂处理的人淋巴细胞中，乙醛诱导的姐妹染色单体交换频率增加。
Mutat Res. 1991 Nov;264(3):103-7. doi: 10.1016/0165-7992(91)90124-m.
3
Cytogenetic effects of paraoxon and methyl-parathion on cultured human lymphocytes: SCE, clastogenic activity and cell cycle delay.对氧磷和甲基对硫磷对培养的人淋巴细胞的细胞遗传学效应：姐妹染色单体交换、致断裂活性和细胞周期延迟。
Int Arch Occup Environ Health. 1984;54(3):195-200. doi: 10.1007/BF00379049.
4
Influence of chronic ethanol uptake and acute acetaldehyde treatment on the chromosomes of bone-marrow cells and peripheral lymphocytes of Chinese hamsters.
Mutat Res. 1981 Apr;88(4):389-95. doi: 10.1016/0165-1218(81)90030-6.
5
The frequency of sister chromatid exchanges in human lymphocytes treated with ethanol and acetaldehyde.乙醇和乙醛处理的人淋巴细胞中姐妹染色单体交换的频率。
Hereditas. 1982;97(2):301-3. doi: 10.1111/j.1601-5223.1982.tb00774.x.
6
Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: acetaldehyde not ethanol is mutagenic.
Mutat Res. 1986 May;174(1):47-51. doi: 10.1016/0165-7992(86)90075-8.
7
[Thiophosphamide induction of sister chromatid exchanges at various phases in the cell cycle of a Chinese hamster cell culture].[硫代磷酰胺对中国仓鼠细胞培养物细胞周期各阶段姐妹染色单体交换的诱导作用]
Genetika. 1979;15(10):1841-6.
8
Induction and persistence of SCE-inducing damage in human lymphocytes exposed to vinyl acetate and acetaldehyde in vitro.体外暴露于醋酸乙烯酯和乙醛的人淋巴细胞中SCE诱导损伤的诱导和持续存在。
Mutat Res. 1985 Dec;158(3):201-8. doi: 10.1016/0165-1218(85)90086-2.
9
Ni(II) induced changes in cell cycle duration and sister-chromatid exchanges in cultured human lymphocytes.镍（II）诱导培养的人淋巴细胞细胞周期持续时间和姐妹染色单体交换发生变化。
Mutat Res. 1995 Mar;327(1-2):217-25. doi: 10.1016/0027-5107(94)00188-b.
10
Blood ethanol and acetaldehyde levels in Japanese alcoholics and controls.日本酗酒者与对照组的血液乙醇和乙醛水平。
Pharmacol Biochem Behav. 1983;18 Suppl 1:139-40. doi: 10.1016/0091-3057(83)90161-2.

引用本文的文献

1
Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.低 Km 醛脱氢酶（ALDH2）多态性、饮酒行为与外周血淋巴细胞染色体改变
Environ Health Perspect. 1996 May;104 Suppl 3(Suppl 3):563-7. doi: 10.1289/ehp.96104s3563.
2
Cytogenetic effects of low-level exposure to toluene, xylene, and their mixture on human blood lymphocytes.低水平接触甲苯、二甲苯及其混合物对人血淋巴细胞的细胞遗传学效应。
Int Arch Occup Environ Health. 1993;64(8):581-5. doi: 10.1007/BF00517704.
3
Cytogenetic effects of paraoxon and methyl-parathion on cultured human lymphocytes: SCE, clastogenic activity and cell cycle delay.

本文引用的文献

1
Protection of pyridoxal 5'-phosphate against toxicity of acetaldehyde to hepatocytes.5'-磷酸吡哆醛对乙醛致肝细胞毒性的保护作用。
Proc Soc Exp Biol Med. 1981 Dec;168(3):325-9. doi: 10.3181/00379727-168-41280.
2
Simultaneous examination of sister chromatid exchanges and cell replication kinetics in tumor and normal cells in vivo.体内肿瘤细胞与正常细胞姐妹染色单体交换及细胞复制动力学的同步检测
Cancer Res. 1981 Dec;41(12 Pt 1):4973-5.
3
Influence of chronic ethanol uptake and acute acetaldehyde treatment on the chromosomes of bone-marrow cells and peripheral lymphocytes of Chinese hamsters.
对氧磷和甲基对硫磷对培养的人淋巴细胞的细胞遗传学效应：姐妹染色单体交换、致断裂活性和细胞周期延迟。
Int Arch Occup Environ Health. 1984;54(3):195-200. doi: 10.1007/BF00379049.
Mutat Res. 1981 Apr;88(4):389-95. doi: 10.1016/0165-1218(81)90030-6.
4
[Alcohol metabolizing enzymes: biochemical properties, genetic heterogeneity and their possible role in alcohol metabolism in humans (author's transl)].酒精代谢酶：生化特性、遗传异质性及其在人类酒精代谢中的可能作用（作者译）
J Clin Chem Clin Biochem. 1981 Apr;19(4):179-89.
5
Genetic studies on alcohol-metabolizing enzymes: detection of isozymes in human hair roots.酒精代谢酶的遗传学研究：人发根中同工酶的检测
Enzyme. 1980;25(4):281-6. doi: 10.1159/000459265.
6
Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication.日本人肝脏中的乙醇脱氢酶和乙醛脱氢酶：同工酶变异及其在酒精中毒中的可能作用。
Am J Hum Genet. 1980 Jan;32(1):8-15.
7
Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.致突变性试验中的姐妹染色单体交换（SCE）和染色体结构畸变
Hum Genet. 1981;58(3):235-54. doi: 10.1007/BF00294917.
8
Sister-chromatid exchanges: a report of the GENE-TOX program.姐妹染色单体交换：GENE-TOX计划报告
Mutat Res. 1981 Jul;87(1):17-62. doi: 10.1016/0165-1110(81)90003-8.
9
Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese.醛脱氢酶缺乏是日本人饮酒后面部潮红反应的原因。
Lancet. 1981 Oct 31;2(8253):982. doi: 10.1016/s0140-6736(81)91172-7.
10
Lack of effect of ethanol in vitro on human chromosomes.
Ann Genet. 1973 Mar;16(1):55-6.