Hodson D I, Malaker K, Meikle A L, Levitt M
Int J Radiat Oncol Biol Phys. 1984 Oct;10(10):1941-5. doi: 10.1016/0360-3016(84)90275-x.
There are sound radiobiologic and suggestive clinical rationale for superfractionating the radiotherapeutic regimens employed for the therapy of rapidly growing malignancies. Oat cell carcinoma of the bronchus is such a tumor. We report our experience combining aggressive systemic combination chemotherapy with superfractionated radiotherapy for the treatment of "limited" oat cell carcinoma of the bronchus. Overall, patient tolerance was satisfactory and a complete remission rate of 74% was achieved. It remains to be proven, in a prospective randomized fashion, whether this approach is superior to current conventional management.
对于快速生长的恶性肿瘤所采用的放射治疗方案进行超分割治疗，有合理的放射生物学依据及提示性的临床理由。支气管燕麦细胞癌就是这样一种肿瘤。我们报告了将积极的全身联合化疗与超分割放射治疗相结合用于治疗“局限性”支气管燕麦细胞癌的经验。总体而言，患者耐受性良好，完全缓解率达到了74%。这种方法是否优于目前的传统治疗方法，仍有待以前瞻性随机方式加以证实。
