Graves S W, Williams G H
J Clin Endocrinol Metab. 1984 Dec;59(6):1070-4. doi: 10.1210/jcem-59-6-1070.
Levels of a ouabain-like factor (OLF) were measured in amniotic fluid from 49 undigitalized third trimester pregnant women by means of its cross-reactivity in a digoxin RIA and its inhibition of ouabain-sensitive [Na,K]ATPase. The results from these 2 assays were significantly correlated (P less than 0.05). Of the women included in this study, 25 had blood pressures considered normal for their gestational age, while 24 had developed during their current pregnancy blood pressures judged to be elevated. When levels of OLF in the amniotic fluids from the normotensive and hypertensive pregnant women were compared, significantly higher levels were present in the hypertensive group for both assays (P less than 0.002). Further, there was a significant correlation between the diastolic blood pressures of these women at the time of amniocentesis and the amniotic fluid OLF levels determined by either assay (P less than 0.002). These results are consistent with OLF having a role in hypertensive complications of pregnancy.
通过地高辛放射免疫分析（RIA）中的交叉反应性及其对哇巴因敏感的[钠，钾]ATP酶的抑制作用，对49名未使用洋地黄制剂的孕晚期孕妇羊水样本中的一种类哇巴因因子（OLF）水平进行了测定。这两种检测结果显著相关（P<0.05）。本研究纳入的孕妇中，25名孕妇的血压在其孕周时被认为正常，而24名孕妇在本次孕期中血压升高。比较血压正常和高血压孕妇羊水样本中的OLF水平时，两种检测中高血压组的OLF水平均显著更高（P<0.002）。此外，这些孕妇在羊膜穿刺时的舒张压与两种检测方法测定的羊水OLF水平之间存在显著相关性（P<0.002）。这些结果表明，OLF在妊娠高血压并发症中发挥作用。
