Wu S Y, Kollin J, Coodley E, Lockyer T, Lyons K P, Moran E, Parker L N, Yu A C
J Nucl Med. 1984 Nov;25(11):1204-9.
This is a case of striking radioiodine and [99mTc]pertechnetate uptake by disseminated nonthyroidal (gastric) adenocarcinoma. A 65-yr-old man was euthyroid and serum thyroglobulin concentration was normal at 11 ng/ml. Bone-marrow biopsy showed that the metastatic tumor cells were negative for thyroglobulin on immunoperoxidase stain and the secretory product was mucicarmine-positive. We estimate that radioiodine uptake in the normal thyroid gland was less than 10% of total tumor uptake. At autopsy, the stomach was the site of the primary tumor, which had the same cellular and histochemical characteristics as the metastatic lesions in bone and liver. It is emphasized that the use of pertechnetate for screening patients with gastric adenocarcinoma may be clinically useful in the early detection of metastatic lesions.
这是一例播散性非甲状腺（胃）腺癌显著摄取放射性碘和高锝[99mTc]酸盐的病例。一名65岁男性甲状腺功能正常，血清甲状腺球蛋白浓度正常，为11 ng/ml。骨髓活检显示，免疫过氧化物酶染色显示转移瘤细胞甲状腺球蛋白呈阴性，分泌产物黏液卡红染色呈阳性。我们估计正常甲状腺对放射性碘的摄取小于肿瘤总摄取量的10%。尸检时，胃是原发性肿瘤的部位，其细胞和组织化学特征与骨和肝转移灶相同。需要强调的是，使用高锝酸盐对胃腺癌患者进行筛查可能对早期发现转移灶具有临床意义。
