一种在早期基因启动子区域插入外源DNA的多瘤病毒的分离。
Isolation of a polyomavirus with an insertion of foreign DNA in the early gene promoter region.
作者信息
Clark K L, Bendig M M, Folk W R
出版信息
J Virol. 1984 Dec;52(3):1032-5. doi: 10.1128/JVI.52.3.1032-1035.1984.
Abstract
We have isolated a polyomavirus with 134 base pairs of foreign DNA between the origin of replication and the early promoter. The insertion reduces the infectivity of the virus by interfering with events required for the initiation of infection. mRNA transcripts from the early region exhibit a marked heterogeneity of 5' termini.
摘要
我们分离出了一种多瘤病毒，其复制起点和早期启动子之间有134个碱基对的外源DNA。这种插入通过干扰感染起始所需的事件降低了病毒的感染性。早期区域的mRNA转录本在5'末端表现出明显的异质性。
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