Hedman L A, Lundin P M
Lymphology. 1977 Dec;10(4):185-91.
The influence of prednisolone on the thoracic duct cells of rats was measured by the cell count in lymph at different times after a single injection and correlated with lymphocytolysis in lymphoid tissues. In both control and neonatally thymectomized animals there was a marked fall in the cell count and flow at 3 hours and the percentage reduction was greater in thymectomized animals. Restitution was rapid in both groups and pretreatment levels were regained in 17 hours. The blood mononuclear cells followed the same pattern. In animals with an intact thymus adrenalectomy causes a significant increase in thoracic duct cell counts but in neonatally thymectomized animals thoracic duct lymph is unchanged after adrenalectomy. It can be concluded that in the rat lymphocyte level in the circulating pool is thymus dependent but restoration of the circulating cell count after steroid induced involution is independent of intact thymic function. Our data support the hypothesis of lymphocyte trapping and redistribution as a major mechanism after a single cortisone dose.
通过单次注射后不同时间点淋巴液中的细胞计数来测定泼尼松龙对大鼠胸导管细胞的影响，并将其与淋巴组织中的淋巴细胞溶解相关联。在对照动物和新生期胸腺切除的动物中，3小时时细胞计数和流量均显著下降，胸腺切除动物的降低百分比更大。两组的恢复都很快，17小时后恢复到预处理水平。血液单核细胞遵循相同模式。在胸腺完整的动物中，肾上腺切除会导致胸导管细胞计数显著增加，但在新生期胸腺切除的动物中，肾上腺切除后胸导管淋巴液没有变化。可以得出结论，在大鼠中，循环池中淋巴细胞水平依赖于胸腺，但类固醇诱导退化后循环细胞计数的恢复与胸腺的完整功能无关。我们的数据支持单次给予可的松后淋巴细胞捕获和重新分布是主要机制的假说。
