Hogan-Dann C M, Fellmeth W G, McGuire S A, Kiley V A
JAMA. 1984;252(20):2862-3.
The neurotoxicity of vincristine sulfate, a commonly used antineoplastic agent, has been well described. A literature review failed to reveal any absolute contraindications to the initial use of vincristine. We describe two patients with nodular sclerosing Hodgkin's disease in whom a rapidly progressive, but reversible, severe polyneuropathy developed when they were given a total of 4 mg of vincristine sulfate. Each was later shown to have the demyelinating form of Charcot-Marie-Tooth syndrome. This association suggests that the use of vincristine is contraindicated in patients with the demyelinating form of Charcot-Marie-Tooth syndrome.
常用抗肿瘤药物硫酸长春新碱的神经毒性已有充分描述。文献综述未发现硫酸长春新碱初始使用的任何绝对禁忌证。我们描述了两名结节硬化型霍奇金病患者，他们在总共接受4毫克硫酸长春新碱治疗后出现了快速进展但可逆的严重多发性神经病。后来发现两人均患有脱髓鞘型夏科-马里-图斯综合征。这种关联表明，脱髓鞘型夏科-马里-图斯综合征患者禁忌使用长春新碱。
