Köster B, Bode U
Klin Padiatr. 1984 Sep-Oct;196(5):253-8. doi: 10.1055/s-2008-1034075.
Primary liver tumors in childhood should be resected totally whenever possible. The chances of long term survival of these patients improved considerably since postoperative chemotherapy has become obligatory. In the treatment of primarily inoperable tumors, initial chemotherapy is given to decrease the size of the tumor and thus achieve conditions for complete resection. For hepatoblastomas, chemotherapy should consist of vincristine, cyclophosphamid, adriamycin and actinomycin-D whereas the hepatocellular carcinoma responds best to anthracyclines. The most effective form of their application will have to be established.
儿童原发性肝肿瘤只要有可能应尽可能进行根治性切除。自从术后化疗成为常规治疗后,这些患者的长期生存几率有了显著提高。对于最初无法手术切除的肿瘤,先给予化疗以缩小肿瘤大小,从而创造完全切除的条件。对于肝母细胞瘤,化疗应包括长春新碱、环磷酰胺、阿霉素和放线菌素-D,而肝细胞癌对蒽环类药物反应最佳。必须确定其最有效的应用方式。