Russell I J, Smith J, Dozois R R, Wahner H W, Bartholomew L G
Mayo Clin Proc. 1977 Feb;52(2):91-6.
A 62-year-old woman with incapacitating atherosclerotic vascular occlusive disease was found to have severe hypoproteinemia as a result of Menetrier's disease. That diagnosis was suspected on roentgenographic and gastroscopic examinations and confirmed by examination of full-thickness surgical gastric biopsy specimens. The protein loss from the stomach was significantly decreased by treatment with trimethaphan and atropine and led us to perform proximal gastric vagotomy at the time of endarterectomy. Subsequent protein turnover studies suggest that there has been a significant decrease in protein loss by the stomach. Further evaluation of the possible role of medical and surgical vagotomy in this disease seems warranted.
一名62岁患有致残性动脉粥样硬化血管闭塞性疾病的女性，因门脉高压性胃病被发现患有严重低蛋白血症。通过X线和胃镜检查怀疑该诊断，并经全层手术胃活检标本检查证实。用三甲硫吩和阿托品治疗后，胃蛋白丢失明显减少，这促使我们在动脉内膜切除术时进行近端胃迷走神经切断术。随后的蛋白质周转研究表明，胃蛋白丢失已显著减少。进一步评估药物和手术迷走神经切断术在该疾病中的可能作用似乎是必要的。
