[The antianaphylactic effect of derivatives of 4-oxoquinazoline, 4-oxoquinazol-3-yl-benzoic acid and 4-oxoquinazol-3-yl-acetic acid in the rat].

Derivatives substituted at position 2 of 4-oxochinazolin as well as derivates of oxochinazolin-3-yl-benzoic acid and 4-oxochinazolin-3-yl-acetic acid had been tested for their antianaphylactic activities in the passive (PCA) and/or active cutaneous anaphylaxis (ACA) in rats. At i.p. administration (ACA) or intracutaneous (i.c.) administration (PCA) most of the derivates displayed a moderate antianaphylactic activity which et best could be compared to the theophylline activity. Only the free acids of the 4-oxochinazolin-3-yl-acetic acid derivatives were active at i.c. administration. All compounds tested remained inactive at p.o. administration.