Grupe R, Pietzsch W, Hagen V, Göres E
Pharmazie. 1984 Jul;39(7):484-6.
Derivatives substituted at position 2 of 4-oxochinazolin as well as derivates of oxochinazolin-3-yl-benzoic acid and 4-oxochinazolin-3-yl-acetic acid had been tested for their antianaphylactic activities in the passive (PCA) and/or active cutaneous anaphylaxis (ACA) in rats. At i.p. administration (ACA) or intracutaneous (i.c.) administration (PCA) most of the derivates displayed a moderate antianaphylactic activity which et best could be compared to the theophylline activity. Only the free acids of the 4-oxochinazolin-3-yl-acetic acid derivatives were active at i.c. administration. All compounds tested remained inactive at p.o. administration.
对4-氧代喹唑啉2位取代衍生物以及氧代喹唑啉-3-基苯甲酸和4-氧代喹唑啉-3-基乙酸衍生物进行了测试，观察它们在大鼠被动皮肤过敏反应（PCA）和/或主动皮肤过敏反应（ACA）中的抗过敏活性。腹腔注射（ACA）或皮内注射（PCA）时，大多数衍生物表现出中等程度的抗过敏活性，其活性最佳可与茶碱活性相媲美。只有4-氧代喹唑啉-3-基乙酸衍生物的游离酸在皮内注射时有活性。所有测试化合物口服给药时均无活性。
