Wagner G, Vieweg H, Leistner S
Fachbereich Biowissenschaften der Universität Leipzig.
Pharmazie. 1993 Aug;48(8):576-8.
Title compounds of structure B with an oxo function in position 4 of the triazine ring were synthesized by reaction of the aminocarboxamides A with sodium nitrite in acetic acid. Aminocarbonitriles of structure H yielded with sodium nitrite in acetic acid and hydrochloric acid the 4-chloro derivatives I. These compounds gave with N-nucleophiles, methoxide or thiourea the substances J. Tetracyclic compounds with a hydroxyethyl or a piperidinoethyl residue in position 3 in the triazine ring (E, G) were also prepared. Some of the investigated compounds showed an antianaphylactic activity.
通过氨基甲酰胺A与亚硝酸钠在乙酸中反应，合成了在三嗪环4位具有氧代官能团的结构B的标题化合物。结构H的氨基腈与亚硝酸钠在乙酸和盐酸中反应生成4-氯衍生物I。这些化合物与N-亲核试剂、甲醇盐或硫脲反应生成物质J。还制备了在三嗪环3位具有羟乙基或哌啶基乙基残基的四环化合物（E、G）。一些研究的化合物表现出抗过敏活性。
