氯化铵和氯喹对1型单纯疱疹病毒增殖的抑制作用。
Inhibition of multiplication of herpes simplex virus type 1 by ammonium chloride and chloroquine.
作者信息
Koyama A H, Uchida T
出版信息
Virology. 1984 Oct 30;138(2):332-5. doi: 10.1016/0042-6822(84)90356-8.
PMID:6093369
Abstract
Multiplication of herpes simplex virus type 1 (HSV-1) strain HF in Vero cells was inhibited by ammonium chloride and chloroquine. A series of one-step growth experiments showed that the maturation of intracellular virus was prevented immediately after the addition of weak bases in the late stage of infection, indicating that the site of inhibition by weak bases is some step in the maturation process of HSV-1.
摘要
1型单纯疱疹病毒（HSV-1）毒株HF在非洲绿猴肾细胞（Vero细胞）中的增殖受到氯化铵和氯喹的抑制。一系列一步生长实验表明，在感染后期加入弱碱后，细胞内病毒的成熟立即受到抑制，这表明弱碱的抑制位点是HSV-1成熟过程中的某个步骤。
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