Inhibition of multiplication of herpes simplex virus type 1 by ammonium chloride and chloroquine.

Multiplication of herpes simplex virus type 1 (HSV-1) strain HF in Vero cells was inhibited by ammonium chloride and chloroquine. A series of one-step growth experiments showed that the maturation of intracellular virus was prevented immediately after the addition of weak bases in the late stage of infection, indicating that the site of inhibition by weak bases is some step in the maturation process of HSV-1.