Mandal T K, Chatterjee S N
Z Naturforsch C Biosci. 1984 Jul-Aug;39(7-8):776-80. doi: 10.1515/znc-1984-7-817.
Polymyxin B produced dose dependent changes in the surface topography of the goat erythrocyte cells. Transformation from the normal biconcave discs through crenated structures to the final rounded or spherical shape was recorded by scanning electron microscopy. A maximum of three to four crenations per cell was recorded corresponding to a polymyxin dose of 15.62 micrograms/ml. Transmission electron microscopy of the ultrathin sections of treated or untreated erythrocytes indicated that the crenations were formed by protrusions of the plasma membrane, occurring presumably because of the local increase of membrane fluidity after polymyxin treatment. Changes in the shape of the erythrocytes to the ultimate rounded forms were also indicated by the transmission electron microscopy.
多粘菌素B使山羊红细胞的表面形貌产生剂量依赖性变化。通过扫描电子显微镜记录了从正常双凹圆盘状经皱缩结构最终转变为圆形或球形的过程。每个细胞最多记录到三到四个皱缩，对应多粘菌素剂量为15.62微克/毫升。对处理过或未处理的红细胞超薄切片进行透射电子显微镜观察表明，皱缩是由质膜突出形成的，这可能是由于多粘菌素处理后膜流动性局部增加所致。透射电子显微镜也显示红细胞形状最终转变为圆形。
