Vaeth M, Schultz H P, Von Der Maase H, Engelholm S A, Krag Jacobsen G, Nørgaard-Pedersen B
Acta Radiol Oncol. 1984;23(4):271-85. doi: 10.3109/02841868409136023.
Prognostic factors in carcinoma of the testis were studied in 1058 adult patients treated in Denmark from 1976 to 1980. Separate analyses of the prognostic factors were carried out within the subgroups formed by a classification of the patients according to main histologic type (seminoma, non-seminoma) and the clinicoradiologic stage (I, II and III). The prognosis was measured by relapse-free survival (stage I and II), and survival (stage II and III). The prognostic value of 19 clinical and histologic parameters was evaluated using logrank tests and multiple regression analyses. An elevated HCG level and the size of retroperitoneal metastases were associated with a significantly adverse prognosis for seminoma in stage II. For non-seminomas the following parameters had a significant influence on the prognosis. Stage I: postoperative HCG level, local invasion and number of mitoses. Stage II: size of retroperitoneal metastases, postoperative HCG level, tumour size and local invasion. Stage III: presence of liver or lung metastases, postoperative HCG level, presence of choriocarcinoma or endodermal sinus tumour, and age.
对1976年至1980年在丹麦接受治疗的1058例成年睾丸癌患者的预后因素进行了研究。根据主要组织学类型（精原细胞瘤、非精原细胞瘤）和临床放射学分期（I、II和III期）对患者进行分类，在形成的亚组内分别分析预后因素。通过无复发生存率（I期和II期）和生存率（II期和III期）来衡量预后。使用对数秩检验和多元回归分析评估19个临床和组织学参数的预后价值。II期精原细胞瘤患者中，HCG水平升高和腹膜后转移灶大小与显著不良预后相关。对于非精原细胞瘤，以下参数对预后有显著影响。I期：术后HCG水平、局部侵犯和有丝分裂数。II期：腹膜后转移灶大小、术后HCG水平、肿瘤大小和局部侵犯。III期：肝或肺转移的存在、术后HCG水平、绒毛膜癌或内胚窦瘤的存在以及年龄。
