Kunze D L, Krauhs J M, Orlea C J
Am J Physiol. 1984 Nov;247(5 Pt 2):H811-6. doi: 10.1152/ajpheart.1984.247.5.H811.
The adventitia of the rat aortic arch, with the depressor nerve intact, was separated from the underlying media to obtain a preparation in which the direct effects of norepinephrine on baroreceptor discharge could be examined free of smooth muscle effects. Cyclic stretch was applied to the adventitia to evoke discharge in single aortic baroreceptor fibers. Norepinephrine and phenylephrine in concentrations of 10(-7) to 10(-5) M increased baroreceptor discharge. No effect on discharge was seen with isoproterenol. Phentolamine but not propranolol blocked the increase in discharge produced by norepinephrine. An alpha-adrenergic modulation of baroreceptor discharge that is not dependent on smooth muscle tension has been demonstrated.
在保留减压神经完整的情况下，将大鼠主动脉弓的外膜与其下方的中膜分离，以获得一种可在无平滑肌影响的条件下检测去甲肾上腺素对压力感受器放电直接作用的标本。对该外膜施加周期性拉伸以诱发单个主动脉压力感受器纤维放电。浓度为10^(-7)至10^(-5) M的去甲肾上腺素和苯肾上腺素可增加压力感受器放电。异丙肾上腺素对放电无影响。酚妥拉明而非普萘洛尔可阻断去甲肾上腺素引起的放电增加。已证实存在一种不依赖于平滑肌张力的压力感受器放电的α-肾上腺素能调节。
