Jones C J, Salisbury R S, Jayson M I
Ann Rheum Dis. 1984 Oct;43(5):710-5. doi: 10.1136/ard.43.5.710.
Lysosomal ultrastructure in circulating lymphocytes and neutrophils from the blood of 22 patients with rheumatoid arthritis or systemic lupus erythematosus undergoing chloroquine therapy has been examined and compared with that of rheumatoid cases receiving alternative forms of treatment and non-rheumatoid controls. The lymphocytes of all 22 patients receiving chloroquine showed a highly significant number of lamellar inclusion bodies (mean 9.3%) compared with only occasional inclusions in six of the 14 rheumatoid and four of the 12 non-rheumatoid controls (means 0.86% and 0.83% respectively). Neutrophils from eight chloroquine-treated patients also showed abnormal granules which were absent from both control groups. These findings confirm our earlier in vitro work which indicated that lymphocytes, compared with neutrophils, had a greater susceptibility to chloroquine action with respect to alterations in lysosomal structure.
对22例正在接受氯喹治疗的类风湿性关节炎或系统性红斑狼疮患者血液中的循环淋巴细胞和中性粒细胞的溶酶体超微结构进行了检查，并与接受其他治疗方式的类风湿病例及非类风湿对照者的溶酶体超微结构进行了比较。所有22例接受氯喹治疗的患者的淋巴细胞显示出大量非常显著的板层状包涵体（平均9.3%），相比之下，14例类风湿患者中的6例以及12例非类风湿对照者中的4例仅偶尔出现包涵体（平均分别为0.86%和0.83%）。8例接受氯喹治疗患者的中性粒细胞也显示出异常颗粒，而两个对照组中均未出现这种情况。这些发现证实了我们早期的体外研究结果，即与中性粒细胞相比，淋巴细胞在溶酶体结构改变方面对氯喹作用的敏感性更高。
