Haines D E, Dietrichs E, Sowa T E
Brain Behav Evol. 1984;24(4):198-220. doi: 10.1159/000121317.
Experimental data which have suggested the probability of connections between the cerebellum and hypothalamus are reviewed. Early studies relied mainly on physiological methods and, in general, concluded that such connections were multisynaptic being relayed via an undetermined number of synapses in the bulbar reticular formation. Recent studies, using horseradish peroxidase techniques, have identified direct connections between cerebellar nuclei and the hypothalamus and between several regions of hypothalamus and the cerebellar cortex. It is proposed that the cerebellum, by way of direct nucleo-hypothalamic projections and the resultant descending hypothalamic projections to visceral centers, has a variety of specific circuits through which it can directly influence autonomic centers. It is further noted that autonomic centers, as exemplified by hypothalamo-cerebellar projections, may have equally specific feedback loops to cerebellar cortex. Direct cerebello-hypothalamic projections and the subsequent diffuse pathways from hypothalamus into a number of forebrain areas may represent circuits responsible for the affective responses seen as a result of cerebellar ablation and/or stimulation.
本文综述了提示小脑与下丘脑之间存在联系可能性的实验数据。早期研究主要依赖生理方法，总体上得出这样的联系是多突触的，通过延髓网状结构中数量不确定的突触进行中继。近期利用辣根过氧化物酶技术的研究，已确定小脑核与下丘脑之间以及下丘脑的几个区域与小脑皮质之间存在直接联系。有人提出，小脑通过直接的核-下丘脑投射以及由此产生的下丘脑向下内脏中枢的投射，具有多种特定回路，通过这些回路它可以直接影响自主神经中枢。还进一步指出，以下丘脑-小脑投射为例的自主神经中枢，可能对小脑皮质有同样特定的反馈回路。小脑与下丘脑之间的直接投射以及随后下丘脑向多个前脑区域的弥散途径，可能代表了因小脑切除和/或刺激而出现的情感反应所涉及的回路。
