Hermus A R, Pieters G F, Pesman G J, Buys W C, Smals A G, Benraad T J, Kloppenborg P W
Clin Endocrinol (Oxf). 1984 Nov;21(5):589-95. doi: 10.1111/j.1365-2265.1984.tb01399.x.
Ten healthy subjects received 200 micrograms of human CRF (hCRF) and 200 micrograms of ovine CRF (oCRF) as an intravenous bolus injection on two different occasions. After hCRF plasma ACTH levels rose significantly (P less than 0.0005, by Friedman's nonparametric analysis of variance) from a basal value of 35 +/- 3 pg/ml (mean +/- SEM) to a peak value of 80 +/- 7 pg/ml 30 min after hCRF administration. This ACTH response was followed by a rise in plasma cortisol levels (P less than 0.0005, by Friedman's test) from a baseline value of 0.32 +/- 0.03 mumol/l to a peak value of 0.56 +/- 0.02 mumol/l 60 min after hCRF. Ovine CRF elicited similar rises in the plasma ACTH and cortisol levels. However, as derived from the faster rate of decline of ACTH and cortisol after hCRF than after oCRF, human CRF had a significantly shorter duration of action than ovine CRF in humans. Human CRF not only stimulated ACTH release by the human pituitary gland but also prolactin release. After hCRF administration prolactin levels rose significantly (P less than 0.005, by Friedman's test) from a basal value of 179 +/- 18 mU/l to a peak value of 288 +/- 34 mU/l at 10 min.
十名健康受试者在两个不同时间接受了200微克人促肾上腺皮质激素释放因子（hCRF）和200微克羊促肾上腺皮质激素释放因子（oCRF）的静脉推注。给予hCRF后，血浆促肾上腺皮质激素（ACTH）水平从基础值35±3皮克/毫升（平均值±标准误）显著升高（通过弗里德曼非参数方差分析，P<0.0005），在给药后30分钟达到峰值80±7皮克/毫升。这种ACTH反应之后是血浆皮质醇水平升高（通过弗里德曼检验，P<0.0005），从基线值0.32±0.03微摩尔/升在hCRF给药后60分钟达到峰值0.56±0.02微摩尔/升。羊促肾上腺皮质激素释放因子引起血浆ACTH和皮质醇水平类似的升高。然而，由于hCRF后ACTH和皮质醇的下降速度比oCRF后更快，人促肾上腺皮质激素释放因子在人体内的作用持续时间明显短于羊促肾上腺皮质激素释放因子。人促肾上腺皮质激素释放因子不仅刺激人垂体释放ACTH，还刺激催乳素释放。给予hCRF后，催乳素水平从基础值179±18毫国际单位/升显著升高（通过弗里德曼检验，P<0.005），在10分钟时达到峰值288±34毫国际单位/升。
