Hargreave T B, Gould J C, Kinninmonth A W, Jeffrey R R, Varma J S, Macintyre C C, Elton R A, Chisholm G D
J Antimicrob Chemother. 1984 Sep;14 Suppl B:263-9. doi: 10.1093/jac/14.suppl_b.263.
A previous randomized trial from this department demonstrated that there was significant reduction in morbidity and post-operative bacteriuria when men undergoing transurethral prostatectomy were given a prophylactic perioperative regimen of 48 h of cefotaxime compared with a no treatment control group. In this paper we report the results of a new randomized trial to determine whether a single dose of cefotaxime given with the induction of anaesthesia would be of equal efficacy to the previous 48 h regimen. We also investigated the ward bacterial flora for cefotaxime resistance before and during the trial. The 48 h regimen was significantly superior to the single dose in terms of the number of men who developed post operative complications and there was also a small but significant reduction in post-operative hospital stay. Forty-eight hours of prophylaxis covers the normal time of post-operative urethral catheterization and this may explain our findings. There was no evidence of emergence of cefotaxime resistant strains.
该科室之前的一项随机试验表明，与未治疗的对照组相比，接受经尿道前列腺切除术的男性患者围手术期给予48小时头孢噻肟预防性治疗方案后，发病率和术后菌尿症显著降低。在本文中，我们报告了一项新的随机试验结果，以确定麻醉诱导时给予单剂量头孢噻肟是否与之前的48小时治疗方案具有同等疗效。我们还在试验前和试验期间调查了病房中对头孢噻肟耐药的细菌菌群。就发生术后并发症的男性患者数量而言，48小时治疗方案明显优于单剂量方案，术后住院时间也有小幅但显著的缩短。48小时的预防覆盖了术后尿道插管的正常时间，这可能解释了我们的研究结果。没有证据表明出现了对头孢噻肟耐药的菌株。
