Gasser T C, Madsen P O
Urologische Klinik, Kantonsspital Basel, Switzerland.
Infection. 1993 Jan-Feb;21(1):49-53. doi: 10.1007/BF01739315.
A study in guinea pigs was performed to investigate the importance of timing, dosage and duration of antimicrobial prophylaxis in urologic surgery. To simulate high-risk conditions, in one group a foreign body was implanted subcutaneously. The prostate and one kidney were cauterized and bacteremia was induced by intravenous injection of an Escherichia coli suspension. Various ciprofloxacin regimens were tested. The results indicate that antimicrobial prophylaxis is beneficial only if administered before or shortly after surgery. Full therapeutic dosage may not be necessary for prophylactic efficacy. Single-dose prophylaxis was as effective as multiple doses. Foreign body infection could be prevented by single-dose prophylaxis.
进行了一项豚鼠研究，以调查泌尿外科手术中抗菌预防的时机、剂量和持续时间的重要性。为模拟高危情况，在一组豚鼠皮下植入异物。对前列腺和一侧肾脏进行烧灼，并通过静脉注射大肠杆菌悬液诱导菌血症。测试了各种环丙沙星给药方案。结果表明，抗菌预防仅在手术前或手术后不久给药才有益。预防效果不一定需要全治疗剂量。单剂量预防与多剂量预防一样有效。单剂量预防可预防异物感染。
