Sinkovics J G, Gyorkey F, Melnick J L, Gyorkey P
Rev Infect Dis. 1984 Sep-Oct;6(5):745-60. doi: 10.1093/clinids/6.5.745.
Acquired immune deficiency syndrome (AIDS) in many aspects resembles formerly recognized immune deficiencies, but in its complexity and presumed viral etiology, it is a unique entity. Examples of overlapping features of AIDS and immune defects, infectious complications, and neoplasms are discussed. It is not known what are the exact underlying mechanisms that permit or prohibit infectious and neoplastic complications among the immunodeficiency syndromes compared, but both overlapping and differing features of these entities are significant enough to hold a clue for future understanding. AIDS resembles feline leukemia as this latter syndrome was described 10 years ago. The retrovirus causing feline leukemia is highly immunosuppressive; preleukemic and viremic cats often succumb to opportunistic infections. If patients with early AIDS harbor retroviruses related to the human T cell leukemia virus in their organs (lymph nodes, bone marrow), serotherapy with monoclonal antibodies directed to this virus may stop and reverse the severe immunosuppression, thus preventing the development of opportunistic infections.
获得性免疫缺陷综合征（艾滋病）在许多方面类似于以前公认的免疫缺陷，但就其复杂性和推测的病毒病因而言，它是一种独特的病症。本文讨论了艾滋病与免疫缺陷、感染性并发症和肿瘤的重叠特征实例。目前尚不清楚在比较的免疫缺陷综合征中，允许或阻止感染性和肿瘤性并发症发生的确切潜在机制是什么，但这些病症的重叠和不同特征都足以成为未来理解的线索。艾滋病类似于10年前描述的猫白血病综合征。引起猫白血病的逆转录病毒具有高度免疫抑制作用；白血病前期和病毒血症期的猫常死于机会性感染。如果早期艾滋病患者的器官（淋巴结、骨髓）中携带与人类T细胞白血病病毒相关的逆转录病毒，用针对该病毒的单克隆抗体进行血清疗法可能会阻止并逆转严重的免疫抑制，从而预防机会性感染的发生。
