Brun-Vézinet F, Rouzioux C
Rev Fr Transfus Immunohematol. 1984 Sep;27(4):445-54. doi: 10.1016/s0338-4535(84)80140-3.
All the epidemiological features suggest that the acquired immunodeficiency syndrome (AIDS) is caused by a single transmissible agent and surely a virus. First, cytomegalovirus, Epstein-Barr virus and hepatitis B virus have been proposed as possible etiological agents of AIDS. A direct link between ubiquitous viruses and the occurrence of the disease has been discarded. At present time, etiological researches provide evidence that retroviruses are the best candidates for the etiology of AIDS. These agents could be directly responsible of the profound suppression of the cell-mediated immunity observed in patients with AIDS. Two human retroviruses are now proposed: human T-cell leukemia virus (HTLV) or lymphadenopathy associated virus (LAV). Moreover simian AIDS (SAIDS) occurred spontaneously at several primate centers in USA; a retrovirus partially related to Mason Pfizer monkey virus appears to be the etiologic agent of SAIDS.
所有流行病学特征表明，获得性免疫缺陷综合征（艾滋病）由单一可传播病原体引起，且肯定是一种病毒。首先，巨细胞病毒、爱泼斯坦-巴尔病毒和乙型肝炎病毒曾被提出可能是艾滋病的病原体。普遍存在的病毒与该疾病发生之间的直接联系已被排除。目前，病因学研究提供证据表明逆转录病毒是艾滋病病因的最佳候选者。这些病原体可能直接导致艾滋病患者中观察到的细胞介导免疫的严重抑制。现在提出两种人类逆转录病毒：人类T细胞白血病病毒（HTLV）或淋巴结病相关病毒（LAV）。此外，美国几个灵长类动物中心自发出现了猴艾滋病（SAIDS）；一种与梅森- Pfizer猴病毒部分相关的逆转录病毒似乎是SAIDS的病原体。
