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获得性免疫缺陷综合征(艾滋病)中可能存在的病毒相互作用。

Possible viral interactions in the acquired immunodeficiency syndrome (AIDS).

作者信息

Hirsch M S, Schooley R T, Ho D D, Kaplan J C

出版信息

Rev Infect Dis. 1984 Sep-Oct;6(5):726-31. doi: 10.1093/clinids/6.5.726.

Abstract

Viral interactions may occur whenever a host is infected simultaneously with two viruses. Persons at high risk for acquired immunodeficiency syndrome (AIDS) may provide a substrate for such interactions. These could include complementary immunosuppression, potentiation of infection by altered receptors or genetic complementation, phenotypic mixing, or genetic recombination. The possibility of such interactions should be considered in the pathogenesis of AIDS.

摘要

每当宿主同时感染两种病毒时,就可能发生病毒相互作用。获得性免疫缺陷综合征(艾滋病)高危人群可能为这种相互作用提供了一个平台。这些相互作用可能包括互补性免疫抑制、受体改变或基因互补导致的感染增强、表型混合或基因重组。在艾滋病发病机制中应考虑到这种相互作用的可能性。

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