Kew M C, Song E, Dusheiko G M
S Afr Med J. 1984 Dec 1;66(22):835-7.
The aetiological associations of hepatocellular carcinoma in 25 White South African patients were assessed. The most frequent association was cirrhosis, which was present in 13 out of 23 patients (56,5%)--7 had alcoholic cirrhosis, 5 (including 1 of those with alcoholic cirrhosis) markers of current or past hepatitis B virus infection, 1 idiopathic haemochromatosis, and 1 no obvious cause. Two further patients in whom the presence or absence of cirrhosis could not be ascertained with certainty also drank to excess. Markers of current hepatitis B virus infection were detected in 24,5% of the patients and evidence of current or past infection in 45,5%. These prevalences are lower than those in matched South African Blacks with hepatocellular carcinoma, but are significantly higher than those in White blood donors. Two young female patients had taken oral contraceptives and another had taken conjugated equine oestrogens.
对25名南非白人肝细胞癌患者的病因关联进行了评估。最常见的关联是肝硬化，23名患者中有13名（56.5%）存在肝硬化——7名有酒精性肝硬化，5名（包括1名酒精性肝硬化患者）有现患或既往乙型肝炎病毒感染标志物，1名患特发性血色素沉着症，1名病因不明。另外两名无法确定是否存在肝硬化的患者也饮酒过量。24.5%的患者检测出现患乙型肝炎病毒感染的标志物，45.5%的患者有现患或既往感染的证据。这些患病率低于与之匹配的南非黑人肝细胞癌患者，但显著高于白人献血者。两名年轻女性患者曾服用口服避孕药，另一名曾服用结合马雌激素。
