Chatterjee D K, Raether W, Iyer N, Ganguli B N
Z Parasitenkd. 1984;70(5):569-73. doi: 10.1007/BF00926587.
The anti-amoebic action of the bipyridyl antibiotic caerulomycin was assessed in vitro and in vivo using various strains of Entamoeba histolytica from polyxenic, axenic and monoxenic cultures. Minimum inhibition concentrations of caerulomycin (metronidazole) were 7.5 (5), 15.6(1.95) and 60 (2.5) micrograms/ml against polyxenic, axenic and monoxenic cultures of E. histolytica, respectively. The ED50 values ascertained in golden hamsters (extraintestinal amoebiasis) and rats (intestinal amoebiasis) after the oral route were 136 and 199 mg/kg (X4), respectively. Metronidazole proved to be approximately four times more active against tissue forms of E. histolytica than caerulomycin [ED50 of metronidazole: less than 40 mg/kg (X4)]. The antibiotic was slightly superior to metronidazole in its action on lumen forms of E. histolytica [ED50 of metronidazole: 233 mg/kg (X4)]. The antibiotic was in some cases toxic to hamsters and rats within the therapeutic range.
使用来自多菌培养、单菌培养和无共生物培养的多种溶组织内阿米巴菌株，在体外和体内评估了联吡啶抗生素天蓝霉素的抗阿米巴作用。天蓝霉素（甲硝唑）对溶组织内阿米巴多菌培养、单菌培养和无共生物培养的最小抑菌浓度分别为7.5（5）、15.6（1.95）和60（2.5）微克/毫升。经口途径给药后，在金黄仓鼠（肠外阿米巴病）和大鼠（肠阿米巴病）中确定的半数有效剂量（ED50）分别为136和199毫克/千克（X4）。事实证明，甲硝唑对溶组织内阿米巴组织型的活性比天蓝霉素高约四倍[甲硝唑的ED50：小于40毫克/千克（X4）]。该抗生素对溶组织内阿米巴肠腔型的作用略优于甲硝唑[甲硝唑的ED50：233毫克/千克（X4）]。在某些情况下，该抗生素在治疗范围内对仓鼠和大鼠有毒性。
