Jasim S, Tjälve H
Acta Pharmacol Toxicol (Copenh). 1984 Oct;55(4):263-9. doi: 10.1111/j.1600-0773.1984.tb01980.x.
The administration of sodium diethyldithiocarbamate to 18 day pregnant mice, which previously had been given 109Cd2+ or 203Hg2+ was found to result in increased levels of the metals in the foetuses, in comparison with mice given the 109Cd2+ or 203Hg2+ alone. The level of 109Cd2+ in some foetal tissues was increased 30-60 times. In the animals given 203Hg2+ 3-5 times higher concentrations were seen in most foetal tissues of the sodium diethyldithiocarbamate-treated animals compared with animals not treated with this substance. Cadmium and mercury were shown to form highly lipophilic complexes with diethyldithiocarbamate and a facilitated transfer of these complexes through the placental membranes probably explains the increased uptake of the metals in the foetuses.
给妊娠18天的小鼠注射二乙基二硫代氨基甲酸钠，这些小鼠此前已接受过109Cd2+或203Hg2+，结果发现与仅接受109Cd2+或203Hg2+的小鼠相比，胎儿体内金属含量增加。某些胎儿组织中的109Cd2+水平增加了30 - 60倍。在接受203Hg2+的动物中，与未用该物质处理的动物相比，二乙基二硫代氨基甲酸钠处理的动物大多数胎儿组织中的浓度高出3 - 5倍。已证明镉和汞与二乙基二硫代氨基甲酸钠形成高度亲脂性复合物，这些复合物通过胎盘膜的促进转运可能解释了胎儿对金属摄取的增加。
