Krasnikova T L, Radiukhin V A, Il'inskiĭ O B, Shkhvatsabaia I K, Parfenova E V
Biull Eksp Biol Med. 1984 Dec;98(12):661-3.
The beta-adrenoreceptor density in intact lymphocytes of peripheral blood of normotensive and hypertensive adults was measured by the radioligand binding technique with the use of 3H-dihydroalprenolol. The density of beta-adrenoreceptors was found to be higher in lymphocytes of hypertensive subjects while the number of the receptors was equal to 2076 +/- 208 and 1461 +/- 175 receptors per cell, respectively, in hypertensive and normotensive subjects. The dissociation constants in both cases varied from 0.4 to 1.8 nM. Probably, the decreased responses to the adrenergic agents in hypertensive subjects are not connected with the decreased number of beta-adrenoreceptors and may be due to alterations in postreceptor events.
利用放射性配体结合技术，以3H-二氢烯丙洛尔为配体，测定了正常血压和高血压成年人外周血完整淋巴细胞中的β-肾上腺素能受体密度。结果发现，高血压患者淋巴细胞中的β-肾上腺素能受体密度较高，高血压患者和正常血压患者的受体数量分别为每个细胞2076±208和1461±175个受体。两种情况下的解离常数均在0.4至1.8 nM之间变化。高血压患者对肾上腺素能药物反应降低可能与β-肾上腺素能受体数量减少无关，而可能是由于受体后事件的改变所致。
