Gabrusenko S A, Naumov V G, Krasnikova T L, Korichneva I L, Masenko V P
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1988;11(2):6-9.
27 patients with dilated cardiomyopathy (DCM) complicated by heart failure (HF) of stages I-IIB were studied. The density of lymphocyte beta 2-adrenoceptors decreased significantly as HF progressed. The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients. This point of view was confirmed by the data of correlation-regression analysis between the general beta 2-adrenoceptors density and hemodynamics data. The identified changes in the number of adrenoceptors reflect the process of cellular receptors desensitization. They should be considered as a possible mechanism of HF development on a molecular level that cause development of refractoriness to routine therapy.
对27例扩张型心肌病（DCM）合并Ⅰ - ⅡB期心力衰竭（HF）患者进行了研究。随着心力衰竭进展，淋巴细胞β2 - 肾上腺素能受体密度显著降低。重度心力衰竭患者循环儿茶酚胺（肾上腺素、去甲肾上腺素）水平显著更高，这可能导致这些患者淋巴细胞β2 - 肾上腺素能受体密度更明显降低。一般β2 - 肾上腺素能受体密度与血流动力学数据之间的相关回归分析数据证实了这一观点。所确定的肾上腺素能受体数量变化反映了细胞受体脱敏过程。它们应被视为心力衰竭在分子水平发展的一种可能机制，导致对常规治疗产生难治性。
