癌症患者、血友病患者和尿毒症患者中的抗人嗜T淋巴细胞病毒抗体：初步报告。

Anti-HTLV antibodies in cancer patients, hemophiliacs and uremics: a preliminary report.

作者信息

Lynn T C, Hsieh R P, Lin K T, Shen M C, Chen D S, Wang C H, Liu C H, Wang J H, Lai M Y, Liou M F

出版信息

Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1984 Aug;17(3):172-6.

Abstract

A total of 132 sera were studied for anti-HTLV antibodies using the Biotech ELISA test. Among the HTL group, two were, one, and the other two (+/-). Among 23 hemophiliacs one was. None of the lympho- and myelo-proliferative disorders, chronic uremics and normal controls showed positive results. Our results show that the ELISA anti-HTLV test is quite specific for HTL and related disorders, but the antibody titers may be low in some cases in the late stage. The significance of frequent high ELISA readings in hepatomas and NPCs awaits for further studies. The occurrence of one hemophiliac with definite positive anti-HTLV calls for a routine screening of the blood preparations for HTLV.

摘要

使用生物技术酶联免疫吸附测定（ELISA）试验对总共132份血清进行了抗人嗜T淋巴细胞病毒（HTLV）抗体研究。在HTL组中，两份血清呈阳性，一份呈弱阳性，另两份呈可疑阳性（±）。在23名血友病患者中，有一份呈阳性。淋巴细胞和骨髓增殖性疾病患者、慢性尿毒症患者及正常对照组均未显示阳性结果。我们的结果表明，ELISA抗HTLV试验对HTL及相关疾病具有较高的特异性，但在某些晚期病例中抗体滴度可能较低。肝癌和鼻咽癌患者中ELISA读数频繁偏高的意义有待进一步研究。一名血友病患者抗HTLV呈明确阳性，这就要求对血液制品进行HTLV常规筛查。