Meyer M S, Amerilio N, Alon R, Edelstein S, Shibolet S
Digestion. 1984;30(4):200-3. doi: 10.1159/000199108.
Rats were gastrectomized, and the intestinal absorption and fecal excretion of cholecalciferol were studied following the administration of radioactive cholecalciferol, either by subcutaneous injection or with the aid of a gastric tube. From measurements of radioactivity in feces and sera it has been possible to establish that gastrectomy in rats results in impaired intestinal absorption and increased fecal excretion of cholecalciferol. These findings indicate that gastrectomy alters the nutritional status of vitamin D, and may explain the high incidence of osteomalacia as a complication of gastrectomy.
将大鼠进行胃切除术后，通过皮下注射或借助胃管给予放射性胆钙化醇，研究了胆钙化醇的肠道吸收和粪便排泄情况。通过测量粪便和血清中的放射性，已证实大鼠胃切除术后胆钙化醇的肠道吸收受损且粪便排泄增加。这些发现表明胃切除术改变了维生素D的营养状况，并可能解释了胃切除术后骨软化症作为并发症的高发病率。
