Krawitt E L, Grundman M J, Mawer E B
Lancet. 1977 Dec 17;2(8051):1246-9. doi: 10.1016/s0140-6736(77)92660-5.
Oral vitamin D3 was poorly absorbed by 4 out of 6 patients with primary biliary cirrhosis; absorption was negatively correlated with faecal fat excretion. 25-hydroxylation of vitamin D3 given by mouth or intravenously was not impaired in the patients compared with controls of similar vitamin-D nutritional status. Urinary radioactivity derived from the intravenous dose of vitamin D3 was significantly greater in patients than in controls and was positively correlated with the serum-bilirubin concentration. Excretion in the urine may lead to loss of administered and endogenous vitamin D and thus contribute to vitamin-D deficiency in patients with primary biliary cirrhosis.
6例原发性胆汁性肝硬化患者中有4例口服维生素D3吸收不良；吸收与粪便脂肪排泄呈负相关。与维生素D营养状况相似的对照组相比，原发性胆汁性肝硬化患者口服或静脉注射维生素D3后的25-羟化作用未受损。原发性胆汁性肝硬化患者静脉注射维生素D3后尿中的放射性明显高于对照组，且与血清胆红素浓度呈正相关。经尿液排泄可能导致所给予的维生素D及内源性维生素D流失，从而造成原发性胆汁性肝硬化患者维生素D缺乏。
