Rosing U, Carlström K
Gynecol Obstet Invest. 1984;18(4):199-205. doi: 10.1159/000299081.
Peripheral serum levels of unconjugated (E1) and total (tE1) oestrone, unconjugated oestradiol-17 beta, unconjugated (E3) and total (tE3) oestriol, progesterone, unconjugated dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulphate (DHAS), and urinary tE3 excretion were determined in pre-eclamptic patients at gestational weeks 32 and 36 and in women with normal pregnancy at the corresponding length of gestation. DHA and DHAS were also analyzed in samples taken 6 weeks after delivery. There were no differences between pre-eclamptic and normal subjects in unconjugated oestrogens and progesterone. Serum tE1 and tE3 levels and urinary tE3 were significantly lower, and the E1/tE1 and E3/tE3 ratios significantly higher in the pre-eclampsia patients. Serum DNA and the DHA/DHAS ratio were significantly elevated in the pre-eclampsia patients during pregnancy, while no differences in these respects were found in the samples taken 6 weeks after delivery. There were no differences in serum DHAS levels. The findings are thought to reflect a general decrease in fetoplacental oestrogen production in combination with a reduced hepatic steroid conjugation in pre-eclamptic subjects.
在妊娠32周和36周时，对先兆子痫患者以及相应孕周的正常妊娠女性，测定外周血清中未结合（E1）和总（tE1）雌酮、未结合雌二醇-17β、未结合（E3）和总（tE3）雌三醇、孕酮、未结合脱氢表雄酮（DHA）和硫酸脱氢表雄酮（DHAS）的水平，以及尿中tE3的排泄量。还对产后6周采集的样本进行了DHA和DHAS分析。先兆子痫患者与正常受试者在未结合雌激素和孕酮方面没有差异。先兆子痫患者血清tE1和tE3水平以及尿中tE3显著降低，而E1/tE1和E3/tE3比值显著升高。先兆子痫患者孕期血清DHA和DHA/DHAS比值显著升高，而产后6周采集的样本在这些方面未发现差异。血清DHAS水平没有差异。这些发现被认为反映了先兆子痫患者胎盘雌激素生成普遍减少，同时肝脏类固醇结合减少。
