人类COL1A1 - TK - GAA同线性在非洲绿猴和狒狒（猕猴科）中的保守性及同源性分配

Conservation of the human COL1A1-TK-GAA synteny and homoeologous assignment in the African green monkey and the baboon (Cercopithecoidae).

作者信息

Créau-Goldberg N, Turleau C, Cochet C, Huerre C, Junien C, de Grouchy J

出版信息

Hum Genet. 1984;68(4):333-6. doi: 10.1007/BF00292595.

Abstract

The pro alpha 1 (I) collagen structural gene (COL1A1), the acid alpha-glucosidase (GAA), and the thymidine kinase (TK) genes, known to be closely linked in man (HSA) and mapped to HSA17, were found syntenic in two Cercopithecoidae species, the baboon (Papio papio, PPA) and the African green monkey (Cercopithecus aethiops, CAE) and assigned to homoeologous chromosomes, PPA16 and CAE19, respectively. The assignment of COL1A1 was obtained using two human cDNA probes. Hind III restriction sites found in man were present in the two species. The particular CAE individual used in the experiment showed a polymorphism for one DNA fragment.

摘要

已知在人类（HSA）中紧密连锁并定位于HSA17的原α1（I）型胶原结构基因（COL1A1）、酸性α-葡萄糖苷酶（GAA）和胸苷激酶（TK）基因，在两种猕猴科动物——狒狒（Papio papio，PPA）和非洲绿猴（Cercopithecus aethiops，CAE）中被发现是同线的，并分别定位于同源染色体PPA16和CAE19上。使用两个人类cDNA探针完成了COL1A1的定位。在人类中发现的Hind III限制性酶切位点在这两个物种中也存在。实验中使用的特定CAE个体在一个DNA片段上表现出多态性。