Van Scott E J, Yu R J
J Am Acad Dermatol. 1984 Nov;11(5 Pt 1):867-79. doi: 10.1016/s0190-9622(84)80466-1.
Hyperkeratinization is a primary or fundamental event in a majority of today's skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesion is determined by strength of intercellular bonding. Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxy acids (AHAs). Conversely, bonding is strengthened or enhanced by dehydration, vitamin A deficiency, and some alpha acetoxy acids (AAAs). Agents that control or modify keratinization can be useful in treatment of many skin disorders.
角质化过度是当今大多数皮肤疾病中的一个主要或基本现象。角质化过度通常是由于角质形成细胞黏附增加导致脱屑减少的结果。角质形成细胞黏附的强度由细胞间连接的强度决定。细胞间连接会因水而减弱，并因维甲酸和α羟基酸（AHAs）而减少。相反，脱水、维生素A缺乏和一些α乙酰氧基酸（AAAs）会增强或强化连接。控制或改变角质化的药物可用于治疗多种皮肤疾病。
