Brownstein M H
J Cutan Pathol. 1984 Oct;11(5):457-65. doi: 10.1111/j.1600-0560.1984.tb00402.x.
Several adnexal tumors (e.g., trichoepitheliomas, trichilemmomas, steatocystomas, sebaceous adenomas, and cylindromas) tend to occur as multiple lesions showing autosomal dominant inheritance, sometimes in association with other cutaneous or internal findings. Solitary tumors with the same clinical and histopathologic features are usually trivial non-hereditary lesions. Multiple trichilemmomas are part of Cowden's syndrome, which includes a high incidence of breast cancer in women; multiple sebaceous adenomas and other sebaceous tumors associated with carcinomas of the gastrointestinal tract are part of a syndrome that was first delineated by Bakker and Tjon A Joe.
几种附件肿瘤（如毛发上皮瘤、外毛根鞘瘤、皮脂腺囊肿、皮脂腺腺瘤和圆柱瘤）往往以多发性病变形式出现，呈常染色体显性遗传，有时还伴有其他皮肤或内部表现。具有相同临床和组织病理学特征的孤立性肿瘤通常是无足轻重的非遗传性病变。多发性外毛根鞘瘤是考登综合征的一部分，该综合征在女性中乳腺癌发病率较高；多发性皮脂腺腺瘤和其他与胃肠道癌相关的皮脂腺肿瘤是由巴克尔和特容·阿·乔首次描述的一种综合征的一部分。
