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柯萨奇病毒B组基因组同源性比较：以克隆的柯萨奇病毒B3基因组片段为探针

A comparison of genomic homologies among the coxsackievirus B group: use of fragments of the cloned coxsackievirus B3 genome as probes.

作者信息

Tracy S

出版信息

J Gen Virol. 1984 Dec;65 ( Pt 12):2167-72. doi: 10.1099/0022-1317-65-12-2167.

DOI:10.1099/0022-1317-65-12-2167
PMID:6096493
Abstract

Using fragments of the cloned coxsackievirus B3 (CB3) genome as hybridization probes, regions in the CB3 genome with widely varying homology to heterologous CB serotype genomes have been demonstrated. A region composed of about 3.2 to 3.5 kbp of the CB3 genome in the 5' half of the map is essentially unique to CB3 and exhibits little or no homology with heterologous CB serotype RNAs. The non-coding terminal 5' end of the CB3 genome is well-conserved among the CB serotype RNAs tested. A sequence in the P3 region of the CB3 genome is also well conserved among heterologous CB serotypes.

摘要

使用克隆的柯萨奇病毒B3（CB3）基因组片段作为杂交探针，已证明CB3基因组中与异源CB血清型基因组具有广泛不同同源性的区域。在图谱5' 端一半中由CB3基因组约3.2至3.5 kbp组成的区域基本上是CB3特有的，与异源CB血清型RNA几乎没有同源性。在测试的CB血清型RNA中，CB3基因组的非编码末端5' 端是高度保守的。CB3基因组P3区域中的一个序列在异源CB血清型中也高度保守。

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