柯萨奇病毒B3的复制酶基因
Replicase gene of coxsackievirus B3.
作者信息
Stålhandske P O, Lindberg M, Pettersson U
出版信息
J Virol. 1984 Sep;51(3):742-6. doi: 10.1128/JVI.51.3.742-746.1984.
Abstract
A cDNA copy covering two-thirds of the coxsackievirus B3 genome was cloned in the PstI site of the pBR322 vector. A nucleotide sequence containing the gene for the viral replicase and the 3' noncoding region of the coxsackievirus B3 genome was determined. The predicted amino acid sequence of the coxsackievirus B3 replicase was shown to be remarkably similar to that of the poliovirus 1 replicase. The 3' noncoding region, in contrast, was only weakly homologous to the poliovirus 1 sequence but showed a close relationship to the sequence of swine vesicular disease virus, a variant of coxsackievirus B5. A 13-nucleotide-long segment located near the polyadenylic acid junction is conserved in several members of the enterovirus group and may thus serve an important function during replication of viral RNA.
摘要
将覆盖柯萨奇病毒B3基因组三分之二的互补DNA（cDNA）拷贝克隆到pBR322载体的PstI位点。确定了包含病毒复制酶基因和柯萨奇病毒B3基因组3'非编码区的核苷酸序列。结果显示，柯萨奇病毒B3复制酶的预测氨基酸序列与脊髓灰质炎病毒1复制酶的序列非常相似。相比之下，3'非编码区与脊髓灰质炎病毒1的序列仅有微弱的同源性，但与柯萨奇病毒B5的变种猪水疱病病毒的序列关系密切。位于多聚腺苷酸连接处附近的一段13个核苷酸长的片段在肠道病毒组的几个成员中是保守的，因此可能在病毒RNA复制过程中发挥重要作用。
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