Kishimoto C, Tamaki S, Matsumori A, Tomioka N, Kawai C
Jpn Circ J. 1984 Dec;48(12):1358-61. doi: 10.1253/jcj.48.1358.
We studied the effects of Coenzyme Q10 (CoQ10) on DBA/2 mice inoculated with the M variant of encephalomyocarditis virus. The mice were treated as follows: 1) CoQ group (n = 49); CoQ10 1.0 mg (0.1 ml) X 2/day (0.1 mg/g/day), 2) control group (n = 55); sham-liquid 0.1 ml X 2/day. These treatments were intraperitoneally performed every day on days -1 to 12. In both groups, we determined the heart and serum contents of CoQ9 and CoQ10, which are the biologically active forms of CoQ in mice, in the mice killed on days 3-4 and 7. There was no significant change in the cumulative incidence of myocarditis in both groups. The survival rate was significantly higher on days 5-12 in the CoQ group than in the control group. There were significant increases of CoQ9 content on days 3-4, and CoQ10 content on days 3-4 and 7, in the heart in the CoQ group as compared with the control group. There was no significant change in the serum content of CoQ9 in both groups. The marked increase of the serum CoQ10 content seen in the CoQ group was due to the results of the exogenous administration of CoQ10. Thus, it may be concluded that CoQ10 may have a protective effect against viral myocarditis in man, in whom CoQ10 is only an active form of CoQ.
我们研究了辅酶Q10（CoQ10）对接种脑心肌炎病毒M变种的DBA/2小鼠的影响。小鼠的处理方式如下：1）CoQ组（n = 49）；CoQ10 1.0毫克（0.1毫升）×2/天（0.1毫克/克/天），2）对照组（n = 55）；假液体0.1毫升×2/天。在第-1天至第12天每天进行腹腔注射。在第3 - 4天和第7天处死的小鼠中，我们测定了小鼠体内CoQ9和CoQ10的心脏和血清含量，它们是小鼠体内CoQ的生物活性形式。两组心肌炎的累积发病率均无显著变化。CoQ组在第5 - 12天的存活率显著高于对照组。与对照组相比，CoQ组心脏中CoQ9含量在第3 - 4天显著增加，CoQ10含量在第3 - 4天和第7天显著增加。两组血清中CoQ9含量均无显著变化。CoQ组血清CoQ10含量的显著增加是由于外源性给予CoQ10的结果。因此，可以得出结论，CoQ10可能对人类病毒性心肌炎具有保护作用，在人类中CoQ10只是CoQ的一种活性形式。
