Parker S, Udani M, Gavaler J S, Van Thiel D H
Neurobehav Toxicol Teratol. 1984 Jul-Aug;6(4):313-8.
Cimetidine, ranitidine or water were administered to pregnant rats from the 12th day of pregnancy through weaning at 21 days of age. The effects of such treatments upon the male progeny were evaluated. Anogenital distance and indices, measures of masculinity, were found to be reduced (p less than 0.05) in pups of cimetidine-exposed dams but not in the pups obtained from either the ranitidine or water controls. In addition, at 55 days and 110 days of age, the testes and ventral prostate-seminal vesicles (androgen responsive tissues) of the rats exposed to cimetidine were smaller (p less than 0.05) than those of the other two groups. Moreover, at both 55 and 110 days of age, the testosterone levels were reduced (p less than 0.05) in these same pups. Despite the fact that the cimetidine-exposed animals had reduced testosterone levels compared to the other two groups, the LH levels did not differ between the three groups. Finally, both before and after exogenous androgen replacement, the sexual behavior of the cimetidine exposed animals was diminished when compared to that of the other two groups. These results suggest that cimetidine but not ranitidine adversely affects male androgenization and neuroendocrine programming and suggests that its use in pregnant women may adversely affect the adult sexual behavior and development of their male progeny.
从妊娠第12天至幼崽21日龄断奶期间，给怀孕大鼠施用西咪替丁、雷尼替丁或水。评估了此类处理对雄性后代的影响。发现暴露于西咪替丁的母鼠所产幼崽的肛殖距和指数（男性化指标）降低（p<0.05），而雷尼替丁或水对照组所产幼崽则未出现这种情况。此外，在55日龄和110日龄时，暴露于西咪替丁的大鼠的睾丸和腹侧前列腺-精囊（雄激素反应性组织）比其他两组的小（p<0.05）。而且，在55日龄和110日龄时，这些幼崽的睾酮水平均降低（p<0.05）。尽管与其他两组相比，暴露于西咪替丁的动物的睾酮水平降低，但三组之间的促黄体生成素水平并无差异。最后，与其他两组相比，在外源性雄激素替代前后，暴露于西咪替丁的动物的性行为均减弱。这些结果表明，西咪替丁而非雷尼替丁会对雄性雄激素化和神经内分泌编程产生不利影响，并表明其在孕妇中的使用可能会对其雄性后代的成年性行为和发育产生不利影响。
