Gupta C, Shapiro B H, Yaffe S J
Pediatr Pharmacol (New York). 1980;1(1):55-62.
The effect of prenatal exposure to phenobarbital (40mg/Kg/day from day 12 to day 19 of pregnancy) on sexual development of male offspring was investigated. Anogenital distance of the male offspring exposed to phenobarbital was significantly smaller. Testicular descent was delayed by 1-3 days, but the age of onset of puberty did not change. Fertility was reduced significantly (P less than .05) in phenobarbital exposed animals compared to that of control. Upon sacrifice, the weight of the seminal vesicles of treated rats was smaller compared to control, but the weight of liver was increased. Hormone measurement in adult age showed a significant reduction in both testosterone and luteinizing hormone levels in the phenobarbital exposed males. Moreover, prenatal treatment with phenobarbital produced an elevated level of cytoplasmic androgen receptor in the seminal vesicles of the adult rats. These findings suggest that phenobarbital treatment during prenatal development can produce some permanent alterations in the process of sexual maturation.
研究了孕期接触苯巴比妥（孕期第12天至第19天，40毫克/千克/天）对雄性后代性发育的影响。接触苯巴比妥的雄性后代的肛门生殖器距离显著更小。睾丸下降延迟1 - 3天，但青春期开始年龄未改变。与对照组相比，接触苯巴比妥的动物生育力显著降低（P小于0.05）。处死后，与对照组相比，经处理大鼠的精囊重量更小，但肝脏重量增加。成年期激素测量显示，接触苯巴比妥的雄性大鼠的睾酮和促黄体生成素水平均显著降低。此外，孕期用苯巴比妥处理使成年大鼠精囊中的细胞质雄激素受体水平升高。这些发现表明，孕期发育期间接触苯巴比妥可在性成熟过程中产生一些永久性改变。
