Prause J U, Jensen O A, Eisgart F, Hansen U, Kieffer M
Ophthalmologica. 1984;189(4):221-8. doi: 10.1159/000309413.
A new syndrome consisting of bilateral diffuse malignant uveal melanoma and simultaneous occurrence of another systemic malignant neoplasm was described in 6 patients in 1982. The present study reports a seventh case. Our patient was younger than the patients previously reported. He had large cell carcinoma of the right lung. The bilateral intraocular neoplasm was characterized as a diffuse malignant uveal melanoma of the mixed cell type by light microscopy and by transmission electron microscopy. All parts of the tumor contained S-100 protein. In addition to the two primary neoplasms, the patient had a combination of Ota's and Ito's naevi on the left side.
1982年，6例患者被描述为一种新综合征，其特征为双侧弥漫性恶性葡萄膜黑色素瘤并同时出现另一种全身性恶性肿瘤。本研究报告了第7例病例。我们的患者比之前报道的患者更年轻。他患有右肺大细胞癌。通过光学显微镜和透射电子显微镜检查，双侧眼内肿瘤被定性为混合细胞型弥漫性恶性葡萄膜黑色素瘤。肿瘤的所有部位均含有S-100蛋白。除了这两种原发性肿瘤外，患者左侧还有太田痣和伊藤痣并存。
