Peskine F, Astruc J, Rodiére M, Echenne B, Brunel D
Pathol Biol (Paris). 1984 Dec;32(10):1040-2.
Twenty-seven septicemia, 2 urinary tract infections and 2 meningitis were treated with Cefotaxime. The pathogenic organisms were most often entero-bacteria (16 E. coli, 2 Klebsiella, 2 Enterobacter cloacae, 1 Proteus, 1 Acinetobacter); sometimes they were Streptococcus (5 Streptococcus D, 3 Streptococcus B, 1 Streptococcus Salivarius). Cefotaxime was given alone to 16 patients, in association to an aminoglycoside in 15 cases. It was administered by infusion over 30 minutes every 8 hours in a daily dose of 150 mg/kg (during 10 days in case of septicemia and during 18 days if it was a meningitis). A clinical and bacteriological success was obtained in 86% of the 22 cases caused by Enterobacteria, in one of the 5 septicemia due to Streptococcus D and in the 3 infections caused by Streptococcus B. It may be concluded from these results that cefotaxime may be used in neonate infection due to a Gram-. But when a Listeria or a Streptococcus D is discovered the ampicillin classically prescribed must be maintained.
27例败血症、2例尿路感染和2例脑膜炎患者接受了头孢噻肟治疗。病原菌最常见的是肠杆菌（16株大肠杆菌、2株克雷伯菌、2株阴沟肠杆菌、1株变形杆菌、1株不动杆菌）；有时是链球菌（5株D群链球菌、3株B群链球菌、1株唾液链球菌）。16例患者单独使用头孢噻肟，15例与氨基糖苷类药物联合使用。每8小时静脉滴注30分钟，每日剂量为150mg/kg（败血症患者用药10天，脑膜炎患者用药18天）。由肠杆菌引起的22例病例中，86%取得了临床和细菌学成功，D群链球菌引起的5例败血症中有1例成功，B群链球菌引起的3例感染均成功。从这些结果可以得出结论，头孢噻肟可用于新生儿革兰氏阴性菌感染。但当发现李斯特菌或D群链球菌时，必须继续使用传统规定的氨苄西林。
